The possibility of using anti-human monoclonal antibody CD3 as pan T-cell marker in guinea pigs

The present study was aimed to evaluate the possibility of using anti-human monoclonal antibody CD3 as pan T-cell marker in guinea pigs’ trachea and lung early late manifestations allergic inflammatory process.
 Materials methods.We have studied distribution quantitative changes CD3-positive lymphocytes pigs histological, immunohistochemical, statistical methods conditions experimental Results. Our results revealed applicability anti-Human (Clone SP7, «DAKO», Denmark) cross-reaction with T-cells tracheas lungs. most statistically significant elevation number lymphocytes, comparison control group (p*/**<0.05), observed III stages process. persists even after termination allergen action, which indicates continuation reaction pulmonary local adaptive immunity allergen.
 Conclusions. our may be useful deficiency pig-specific tests. immunohistochemical assessment lungs proved use a panT-cell pigs. We demonstrated activation immune response (T-cells), represented by their changes, predominantly